Signature 2.0 Plus Backpack with Antimicrobial Liner

7 reviews
Color: Pebbled Grey

Ultimate Weekend Companion

The Plus Backpack was designed with enhanced interior capacity and thoughtful exterior organization. Optimal travel features include a lay-flat opening for storing tech, a trolley sleeve for convenient portability and ergonomic shoulder straps with an added sternum strap for a comfortable carry no matter how heavy your load gets. This multi-functional backpack was crafted from premium synthetic leather for ultimate durability and weather resistance.


  • Premium Synthetic Leather | Known for its durability, weather resistance, and is easy-to-clean!
  • Antimicrobial Lining

Capacity: 27L

3.3lbs / 1.5kg

12" x 7" x 20"H


  • Dual-zip main compartment with waterproof zippers
  • 16" external, lay-flat laptop compartment
  • Large, front exterior zip pocket with internal organization
  • 14 internal pockets including 2 velour-lined valuables pockets
  • 6 external pockets including 2 easy-access side zip pockets
  • Bottom zip compartment for additional storage
  • Key clip
  • Adjustable, ergonomic shoulder straps with removable sternum strap
  • Air-mesh back panel for comfort and breathability
  • Trolley sleeve for easy portability when traveling

Antimicrobial Protection

This minimalist laptop backpack is lined with high-quality antimicrobial fabric throughout the large main compartment, front pocket, and laptop compartment. This antibacterial material prevents the growth of bacteria so your personal items stay as sanitary as possible. With this premium travel laptop backpack, you can hygienically store your toiletry bag, hand sanitizer, hand lotion, and other frequently-used small items.

Each style offered in the Signature 2.0 collection is lined with AEGIS® by Microban® antimicrobial fabric. This durable antimicrobial material physically defends against bacteria by puncturing the membrane of microorganisms to stop growth. This keeps clothing, footwear, travel gear, and electronics more hygienic. With AEGIS technology, your everyday VESSEL bag conveniently combats unwanted odors and fights against harmful bacteria.

Padded Laptop Sleeve

Not only does this water-resistant travel backpack provide the durability needed for commuting and traveling, it is equipped with a padded laptop sleeve. This designated laptop compartment opens with a top zip separate from the main compartment to provide optimal organization and easy access. The laptop storage space is lined with high-quality velour to keep your laptop, iPad, chargers, and other electronic devices safe. Because of this padded laptop compartment, the Signature 2.0 Plus Backpack with Antimicrobial Liner is one of the best laptop backpacks for work and business travel. Whether you use it as a carry-on or everyday carry bag (EDC), this best-selling laptop bag has plenty of room for your daily gadgets and gear. 

[Fits up to a 16-inch laptop. Measured with MacBook Pro]

Enhanced Capacity Main Compartment

This water-repellent laptop backpack for men and women offers a 27L capacity main compartment that is perfect for storing all essentials. In the large storage space, you can efficiently stack clothing, toiletries, and more. This additional storage makes the Signature 2.0 Plus with Antimicrobial Liner the ideal school backpack for college students or business backpack for business travelers.

Designated Pockets For Each Accessory

Effortlessly organize daily essentials with 14 internal storage compartments. The Signature 2.0 Plus Backpack with Antimicrobial features two velour-lined pockets that are perfect for safekeeping delicate items like: sunglasses, readers, jewelry, and watches. The plush, velvety lining ensures that valuables stay safe and scratch-free. With small expandable mesh pockets, there is plenty of room for small items like: wallets, chargers, passports, and more. For those that always have a water bottle on hand, there are larger internal mesh sleeves that make great water bottle pockets. With so many organization options, this laptop backpack makes it easy to keep track of essentials while you’re on-the-go.

Lower Footwear Compartment

This laptop backpack for women and men wouldn’t be complete without a compartment for shoes! The roomy footwear compartment provides breathable storage for dirty shoes or clothing. This helps to minimize the spread of harmful germs and bacteria to your clean items. This handy compartment is useful for storing liquids, water bottles, and toiletry bags away from expensive electronics. With the lower footwear compartment, the Signature 2.0 Plus with Antimicrobial makes a great bookbag, work backpack, or gym bag.

2 Easy-Access Vertical Side Pockets

For valuable items you want to avoid storing in the front exterior pocket, safely pack them into concealed zippered pockets. This faux leather laptop backpack offers two vertical, side pockets. These provide anti-theft storage for: your cell phone, wallet, credit cards, and/or keys. You’ll have easy access to these valuables, but no one else! Use the Signature 2.0 Plus Backpack as a daypack, commuter backpack, or travel bag and rest assured your valuables are protected throughout the day.

180-degree Lay Flat Opening

When making your way through airport security, it can be tedious to unpack and repack the electronics in your carry-on travel bag. The Signature 2.0 Plus with Antimicrobial helps eliminate this hassle with its TSA-friendly lay-flat opening. Simply unzip the back panel of this travel laptop backpack and lay it flat to be scanned through x-rays. This 180-degree opening reveals a padded laptop sleeve, tablet pocket, and small slip pockets to provide quick-access to your laptop, iPad, chargers, and other devices. Whether the Signature 2.0 is your everyday carry bag (EDC) or weekend travel bag, it offers the convenience and durability needed for whatever the day calls for.

Trolley Sleeve For Easy Portability

The Signature 2.0 Plus is one of the best backpacks for travel because of its sleek, padded trolley sleeve on the back panel. When you’re trying to navigate busy TSA check-ins and public transportation, simply slide the laptop backpack over the top handle of your favorite rolling suitcase for more mobility. This sleeve keeps your laptop bag secure while you’re on-the-go. 

For other travel bags with trolley sleeves, check out our tote bags and duffels.

Find The Perfect Backpack For Any Occasion

Whether you need a bag that does it all, or a stylish bag for a day in the city, we've made it easy to find the backpack that fits your needs! Compare our backpack styles and enhance your everyday commute, airport travel and everything in between.


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  • look
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  • space
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  • level construction
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헌팅 굿.
United States United States
I recommend this product

Amazing quality

Stylish look with plenty of space and utility.

헌팅 굿.
United States United States
I recommend this product

Amazing quality

Stylish look with plenty of space and utility.

Peter C.
United States United States
I recommend this product

Beautiful bag

Top level construction, smartly designed.

Alison S.
United States United States


Vessel makes rally beautiful bags. They're finished perfectly, stylish, smooth, well made, and thoughtfully designed. However, I find them slightly tight. My last Vessel's zipper broke--probably under stress, perhaps from being slightly overpacked. I received my replacement recently, and once packed, it feels very tight. It's hard to describe--There's a spot for each kind of item--but it feels to me like just not quite enough 'give' in the fabric and build of the pack. I ended up unpacking my Vessel bag and finding a different way to carry my things onto the plane. I still love the design and workmanship of Vessel bags. But I'm not sure how much I'll use it over time.

Manaphan H.

Amazing Quality

Bought four of these bags for my groomsmen. All of them loved the quality and looks of the bag. They can’t stop raving about them as they use them more and more

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